Nephrotic syndrome

Also called Minimal change disease

Nephrotic syndrome is a condition where the kidneys leak large amounts of protein into the urine. This causes swelling, especially around the eyes, ankles and feet. It most often affects young children, usually because of minimal change disease, but it can also affect adults with other kidney conditions or diabetes.

Last updated Nov 9, 2026

What it is

In children, steroid medicine usually works well, although relapses are common.

Treatment in adults depends on the cause. Low protein levels can increase the risk of infections and blood clots, which may need prevention.

Common signs

  • Swelling around the eyes, ankles, feet or tummy
  • Foamy pee
  • Weight gain from fluid
  • Tiredness and loss of appetite

How it is usually diagnosed

  • Urine test for protein
  • Blood tests for albumin, cholesterol and kidney function
  • Kidney biopsy, mainly in adults

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Urine protein results, including home dipstick diaries
  • Albumin and kidney function results
  • Biopsy reports
  • Nephrology letters and steroid courses

Questions to ask your doctor

  • How do I check for a relapse at home?
  • How long will steroid treatment last?
  • Do I need anything to prevent infections or clots?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Fever with tummy pain, a painful swollen leg, or breathlessness: get urgent medical help

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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