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ME/CFS

Also called Myalgic encephalomyelitis, Chronic fatigue syndrome, or CFS

Myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS) is a long-term condition with many symptoms. The most common is extreme tiredness. A key feature is that symptoms get worse after physical or mental activity, often a day or more later (post-exertional malaise). It can affect anyone, including children, and the cause is not known.

Last updated Nov 9, 2026

What it is

Some people improve over time, but many have it for years. It can range from mild to very severe.

There is no cure. Energy management, sleep advice, treating pain and other symptoms, and support from a specialist team can help.

Common signs

  • Extreme tiredness that does not go away with rest
  • Symptoms getting worse after activity
  • Unrefreshing sleep
  • Problems with memory and concentration
  • Dizziness on standing
  • Muscle or joint pain

How it is usually diagnosed

  • Questions about symptoms lasting 3 months or more
  • Blood tests to rule out other conditions

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Blood test results
  • An activity and symptom diary
  • Specialist service letters
  • Energy management plans

Questions to ask your doctor

  • Have other causes been ruled out?
  • How should I manage my energy?
  • Is there a specialist ME/CFS service I can be referred to?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Thoughts of harming yourself, or being unable to eat or drink: get urgent help, call 112 if in danger

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

Sources

Related conditions

FibromyalgiaA long-term condition that causes pain all over the body, tiredness and trouble sleeping. Treatment aims to ease symptoms.Long COVIDSymptoms that continue for weeks or months after a COVID-19 infection, such as tiredness and breathlessness. Most people slowly improve.DepressionA common mental health condition causing persistent low mood and loss of interest that lasts for weeks or months. It can be treated.