Depression

Also called Clinical depression, Major depressive disorder, or Low mood

Depression is more than feeling unhappy for a few days. It is persistent low mood or loss of interest and enjoyment that lasts for weeks or months and affects daily life. It is very common, and it is a real health condition, not a sign of weakness. Most people recover with the right support and treatment.

Last updated Nov 9, 2026

What it is

It can follow life events such as bereavement, stress or illness, but sometimes there is no obvious cause. It often occurs alongside anxiety.

Treatment depends on how severe it is and may include self-help, talking therapies such as CBT, antidepressant medicines, or a combination. Exercise and social contact can also help.

Common signs

  • Continuous low mood or sadness
  • Loss of interest or enjoyment
  • Tiredness and lack of energy
  • Sleeping badly or too much
  • Changes in appetite
  • Feeling hopeless or worthless
  • Thoughts of self-harm or suicide

How it is usually diagnosed

  • A conversation with a GP about symptoms
  • Questionnaires such as PHQ-9
  • Blood tests to rule out physical causes

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Questionnaire scores over time
  • Therapy letters
  • A list of medicines tried, with doses and effects
  • A crisis plan with contacts

Questions to ask your doctor

  • Which treatment would suit me best?
  • How long before I feel better on this medicine?
  • What should I do if I feel worse?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Thoughts of ending your life, or having harmed yourself: call 112

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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