Vitamin B12 or folate deficiency anaemia

Also called B12 deficiency, Folate deficiency, Pernicious anaemia, or Megaloblastic anaemia

Vitamin B12 or folate deficiency anaemia happens when a lack of these vitamins means the body makes abnormally large red blood cells that cannot work properly. Causes include pernicious anaemia (an autoimmune condition that stops B12 being absorbed), a diet low in these vitamins, some gut conditions and some medicines.

Last updated Nov 9, 2026

What it is

It is usually easy to treat with B12 injections or tablets, or folic acid tablets. Some people need treatment for life.

If not treated, low B12 can cause problems with the nerves, memory and balance, which may not fully recover.

Common signs

  • Tiredness and lack of energy
  • Pale or yellow skin
  • A sore, red tongue or mouth ulcers
  • Pins and needles
  • Problems with memory, thinking or balance
  • Feeling low or irritable

How it is usually diagnosed

  • A full blood count
  • Blood tests for B12 and folate levels
  • Sometimes tests for intrinsic factor antibodies

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Full blood count results over time
  • B12 and folate levels
  • Injection schedule
  • Haematology or GP notes

Questions to ask your doctor

  • What is causing my low levels?
  • Do I need injections or tablets, and for how long?
  • When should my blood be checked again?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • New problems walking, severe confusion, or numbness spreading in the legs: get urgent help the same day

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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