Thrombophilia

Also called Factor V Leiden or Blood clotting disorder

Thrombophilia is a condition where the blood has a greater tendency to clot. It can be inherited, such as factor V Leiden or a prothrombin gene change, or develop later, such as antiphospholipid syndrome. Many people with thrombophilia never have a clot, but the risk is higher during pregnancy, after surgery, when immobile or when taking some hormone medicines.

Last updated Nov 9, 2026

What it is

Most people do not need daily treatment. Blood-thinning medicine may be given at higher-risk times, such as after surgery or in pregnancy.

Staying active, keeping hydrated on long journeys and discussing contraception and HRT choices with a doctor help lower the risk.

Common signs

  • Often no symptoms
  • A blood clot in a leg (DVT) or lung (PE)
  • Clots at a young age or in unusual places
  • Repeated miscarriages in some types

How it is usually diagnosed

  • Blood tests for clotting disorders, usually after a clot or with a family history

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Thrombophilia test results
  • Haematology letters
  • Records of past clots
  • Anticoagulant plans

Questions to ask your doctor

  • Do I need blood thinners now?
  • What should I do before surgery or long journeys?
  • Which contraception or HRT is safe for me?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Sudden breathlessness, chest pain or coughing up blood: call 112
  • A painful, swollen, warm leg: get urgent help the same day

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

Sources