Stevens-Johnson syndrome

Also called SJS, Toxic epidermal necrolysis, or TEN

Stevens-Johnson syndrome is a rare but serious condition where the skin and the lining of the mouth, eyes and genitals blister and peel. It is usually a reaction to a medicine, such as some antibiotics, anti-seizure medicines or allopurinol, but can be triggered by an infection. A more severe form is called toxic epidermal necrolysis (TEN).

Last updated Nov 9, 2026

What it is

It needs emergency treatment in hospital, often in a burns or intensive care unit. The medicine that caused it is stopped.

Recovery can take weeks to months. Some people have lasting problems with their eyes or skin. The medicine that caused it must be avoided for life.

Common signs

  • Flu-like symptoms first, such as fever and sore throat
  • A painful red or purple rash that spreads
  • Blisters on the skin, mouth, eyes and genitals
  • Skin peeling off
  • Sore, red eyes

How it is usually diagnosed

  • Examination
  • Questions about recent medicines
  • A skin biopsy

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Hospital discharge letters
  • Allergy records listing the medicine that caused it
  • Dermatology and eye clinic letters

Questions to ask your doctor

  • Which medicine caused this?
  • Which other medicines should I avoid?
  • What follow-up will I need for my eyes and skin?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • A spreading painful rash with blisters, especially after starting a new medicine: call 112

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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