Pyoderma gangrenosum

Also called PG

Pyoderma gangrenosum is a rare condition that causes large, painful sores (ulcers) to develop on the skin, most often on the legs. It is not an infection and not contagious. It is thought to be caused by a problem with the immune system and is often linked to conditions such as inflammatory bowel disease or rheumatoid arthritis.

Last updated Nov 9, 2026

What it is

Sores can grow quickly and can be triggered by minor injuries, including surgery.

Treatment includes steroid creams or tablets and other medicines that calm the immune system, along with careful wound care.

Common signs

  • A small red or purple spot or blister that turns into a sore
  • A painful ulcer with a purple or dark edge
  • Sores that grow quickly
  • Fever or feeling unwell

How it is usually diagnosed

  • Examination by a dermatologist
  • Ruling out infection and other causes with swabs, blood tests and a biopsy

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Dermatology letters
  • Biopsy and swab results
  • Wound care plans and photos
  • Medicine lists

Questions to ask your doctor

  • Is this linked to another condition I have?
  • How should the wound be cared for?
  • How long will treatment take to work?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • A sore that is spreading fast, with fever or feeling very unwell: get urgent help the same day

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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