What it is
Mast cells release chemicals such as histamine, which can cause flushing, itching, tummy problems and, sometimes, anaphylaxis.
Treatment includes avoiding triggers, antihistamines and other medicines. People at risk of anaphylaxis carry adrenaline auto-injectors.
Common signs
- Itchy brown or red spots that swell when rubbed
- Flushing
- Tummy pain and diarrhoea
- Dizziness or fainting
- Bone pain
How it is usually diagnosed
- Examination of the skin
- Blood test for tryptase
- Skin or bone marrow biopsy
Records worth keeping
Keeping these together makes each appointment easier, especially when you see a new doctor:
- Tryptase results over time
- Biopsy reports
- A list of known triggers
- Haematology or dermatology letters
Questions to ask your doctor
- Is it only in my skin or more widespread?
- Which triggers should I avoid?
- Do I need an adrenaline auto-injector?
When to get help right away
Call 112 or go to the nearest emergency department if you have:
- Swelling of the throat, difficulty breathing or collapse: use an adrenaline auto-injector if you have one and call 112
This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.