Angioedema

Angioedema is swelling under the skin, often around the eyes and lips, and sometimes the hands, feet, genitals or throat. It often happens together with hives. Most episodes settle within a few days, but swelling of the tongue or throat can block the airway.

Last updated Nov 9, 2026

What it is

It can be caused by an allergic reaction, by certain medicines (especially ACE inhibitors for blood pressure), by a rare inherited condition (hereditary angioedema), or without an identifiable cause.

Treatment depends on the type: antihistamines and avoiding triggers for allergic angioedema, changing medicines if a drug is responsible, and specific treatments for hereditary angioedema.

Common signs

  • Swelling of the lips, eyes, cheeks, hands or feet
  • The swollen skin may feel hot or painful
  • Sometimes hives, or tummy pain if the gut is affected

How it is usually diagnosed

  • A history of when swelling happens and which medicines you take
  • Allergy tests if an allergy is suspected
  • Blood tests (C4 and C1 inhibitor) for hereditary angioedema

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Photos of episodes with dates
  • A diary of possible triggers
  • Allergy and blood test results
  • An up-to-date medicine list, noting any medicine that caused swelling

Questions to ask your doctor

  • What type of angioedema do I have?
  • Could any of my medicines be the cause?
  • Do I need an emergency plan or adrenaline?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Swelling of the tongue or throat
  • Difficulty breathing or swallowing, or a hoarse voice
  • Feeling faint

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

Sources