Primary biliary cholangitis (PBC)

Also called PBC or Primary biliary cirrhosis

Primary biliary cholangitis (PBC) is a long-term condition where the small bile ducts in the liver become damaged over time. This causes bile to build up and can scar the liver. It is thought to be an autoimmune condition and mostly affects women over 40.

Last updated Nov 9, 2026

What it is

Many people have no symptoms for years and it is found by a routine blood test.

A medicine called ursodeoxycholic acid can slow it down. Other medicines can help itching. A liver transplant may be needed if the liver stops working well.

Common signs

  • Often no symptoms at first
  • Tiredness
  • Itchy skin
  • Dry eyes and mouth
  • Pain in the upper right tummy
  • Yellow skin or eyes later on

How it is usually diagnosed

  • Liver blood tests
  • Antibody blood tests (AMA)
  • Ultrasound or other liver scans
  • Sometimes a liver biopsy

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Liver blood test results over time
  • Antibody test results
  • Liver scan reports
  • Hepatology letters

Questions to ask your doctor

  • How well is the medicine working?
  • How often will my liver be checked?
  • What can help with the itching and tiredness?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Vomiting blood, black poo, sudden swelling of the tummy or confusion: call 112

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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