Neuromyelitis optica

Also called NMO, NMOSD, or Devic's disease

Neuromyelitis optica (NMO) is a rare condition where the immune system attacks the optic nerves and spinal cord. It causes attacks of eye pain and vision loss, and weakness, numbness or bladder problems. It is more common in women and is sometimes confused with multiple sclerosis, but it is treated differently.

Last updated Nov 9, 2026

What it is

Attacks are treated urgently with high-dose steroids and sometimes plasma exchange.

Long-term medicines that calm the immune system reduce the risk of further attacks.

Common signs

  • Eye pain and loss of vision
  • Weakness or numbness in the arms or legs
  • Bladder or bowel problems
  • Persistent hiccups or vomiting

How it is usually diagnosed

  • Blood test for AQP4 or MOG antibodies
  • MRI of the brain and spine
  • Eye tests

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Antibody results
  • MRI reports
  • Attack dates and treatments
  • Neurology letters and a list of medicines

Questions to ask your doctor

  • Which antibody do I have?
  • Which long-term treatment is right for me?
  • What should I do if I have a new attack?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Sudden loss of vision, new weakness or numbness, or difficulty breathing: get urgent medical help

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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