Erythema multiforme

Also called EM or Target lesions

Erythema multiforme is a skin reaction that causes raised spots that often look like targets, with dark circles in the middle and pale rings around them. It is usually triggered by an infection, most often the herpes simplex virus that causes cold sores, and less often by medicines. It usually gets better on its own within 2 to 4 weeks.

Last updated Nov 9, 2026

What it is

The minor form affects only the skin. The major form also affects the lips, mouth, eyes or genitals.

Treatment eases symptoms with antihistamines, creams and mouthwashes. If cold sores trigger repeated episodes, antiviral tablets may prevent them.

Common signs

  • Raised spots that look like targets, often on the hands, feet, arms and legs
  • Itching or burning
  • Blisters or sores on the lips and in the mouth (major form)

How it is usually diagnosed

  • Recognised by how the rash looks
  • Skin biopsy in some cases

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Photos of the rash with dates
  • Notes on triggers such as cold sores or new medicines
  • Dermatology letters

Questions to ask your doctor

  • What triggered it?
  • Should I take antiviral tablets to prevent it?
  • How do I tell it from a more serious drug reaction?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Widespread blistering or peeling skin, sore eyes, or a rash after starting a new medicine with fever: get urgent help

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

Sources