Bullous pemphigoid

Also called Pemphigoid

Bullous pemphigoid is a rare skin condition in which the immune system attacks the layer just under the skin, causing large, tense blisters. It mostly affects people over 70. It often starts with an itchy rash before blisters appear, and it can last months or years.

Last updated Nov 9, 2026

What it is

It is not contagious. Some medicines can trigger it.

Treatment usually involves strong steroid creams or tablets and other medicines that calm the immune system. Blisters need care to prevent infection.

Common signs

  • An itchy, red, raised rash
  • Large, tense blisters on the arms, legs, tummy or skin folds
  • Blisters in the mouth occasionally

How it is usually diagnosed

  • Skin biopsy, including a special test (immunofluorescence)
  • Blood tests for the antibodies involved

Records worth keeping

Keeping these together makes each appointment easier, especially when you see a new doctor:

  • Biopsy and blood test results
  • Dermatology letters and treatment plans
  • Blood sugar, blood pressure and bone checks while on steroids

Questions to ask your doctor

  • Could any of my medicines have triggered it?
  • How long will treatment last?
  • How should I care for the blisters?

When to get help right away

Call 112 or go to the nearest emergency department if you have:

  • Blisters with spreading redness, fever or feeling very unwell, which may be an infection

This page is general information. It is not a diagnosis and does not replace a doctor who knows your history. Medfold keeps your records organised; it does not interpret them.

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